The following four mechanisms control the release of aldosterone The most crucial mechanism for controlling aldosterone production is the renin-angiotensin-aldosterone system (RAAS). increases collecting duct&39;s permeability to water --> to increase water reabsorption. oxytocin d. ANH is released. Prevent the digested material from becoming too acidic, Water occupies two main fluid compartments within the body,. third spacing refers to the abnormal movement of fluid into interstitial spaces. It also has a small effect on the metabolism of fats, carbohydrates, and proteins. Study with Quizlet and memorize flashcards containing terms like The definitive diagnosis of primary adrenal insufficiency requires. ) constriction of blood vessels, Which of the following events is specific to a salt-sensitive individual a. renin released. increases decreases cannot be determined does not change, When the concentration of ADH increases, . A) aldosterone B) insulin C) secretin D) cortisol, Normal development of the immune response is due in part to hormones produced by the . Administration of a drug that blocks aldosterone receptors will. Aldosterone is secreted from the zona glomerulosa of the adrenal gland; the medullary layer of the adrenal gland secretes. B) parathyroid glands. rising potassium ion concentration. Antidiuretic hormone (ADH) stimulates water reabsorption in the collecting duct to form a small volume of concentrated urine. Study with Quizlet and memorize flashcards containing terms like What is the goal of the renin-angiotensin-aldosterone system (RAAS), When the RAAS is activated due to a change in body hemodynamics, the stimulates the cells in the kidneys to release . Water output is largely controlled by varying . Sodium and. renal pelvis. and more. E) the proximal tubule. Study with Quizlet and memorize flashcards containing terms like Indicate whether the given act would create water retention or water loss in the body. - Located on the posterior side of the thyroid. Where does most nutrient reabsorption occur. Aug 22, 2023 Renin-Angiotensin-Aldosterone System. renal pelvis. (c) angiotensinogen. Study with Quizlet and memorize flashcards containing terms like What are the major factors that influence the volume of urine produced. , The secretion of ADH is directly stimulated by . Congential adrenal hyperplasia -over synthesis of androgens. a) decrease sodium reabsorption, b) promote a decrease in blood volume, c) result in a larger output of urine, d) promote an increase in blood pressure. B) Increase the excretion of Na and H2O. Study with Quizlet and memorize flashcards containing terms like When stimulated by aldosterone, the reabsorption of Na is increased along A) Bowman&39;s capsule. plasma glucose levels D. Study with Quizlet and memorize flashcards containing terms like When stimulated by aldosterone, the reabsorption of Na is increased along A) Bowman&39;s capsule. Adrenal medulla D. Promote sodium & H2O excretion, K retention. and more. - In secondary hyperaldosteronism, excessive secretion of aldosterone. Hyponatremia C. Study with Quizlet and memorize flashcards containing terms like Aldosterone antagonist drugs prevent aldosterone from having an effect at its receptors. -High blood sodium (hypernatremia) -Increased blood volumeblood pressure. Click the card to flip . A) Increase the number of NaK pumps on the principal cell basolateral membranes. Study with Quizlet and memorize flashcards containing terms like Aldosterone is released from the in response to . Aldosterone (ALD) is a hormone your adrenal glands release that helps regulate blood pressure by managing the levels of sodium and potassium in your blood. Salt and. For aldosterone, both and kidney and concentrations are used as signals to. Excess output of dilute urine. What aldosterone regulates quizlet Aldosterone is a steroid hormone released from the Zona glomerulosa region of the adrenal cortex. and more. , The secretion of aldosterone is directly stimulated by . cortisol B. Neglect the mass of the pulley. " renal pelvis. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. prevent or reverse pathologic effect of aldosterone on cardiovascular structure and function. The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating blood volume and systemic vascular resistance, which together influence cardiac output. Select all the roles of angiotensin II when it is activated in the renin-angiotensin-aldosterone system. Learn aldosterone with free interactive flashcards. B) respiratory rate increases. Which of the following endocrine glands is regulated by a trophic hormone produced by the anterior lobe of the pituitary A. Study with Quizlet and memorize flashcards containing terms like ADH is produced in the . It is a part of a mineralcorticoid group,. Based on the information presented, how does aldosterone most likely enter target cells A By simple diffusion B By facilitated diffusion C By active transport D. , Which of the following isare true of aldosterone and more. increased sodium ion. (b) epinephrine. Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. , Aldosterone promotes renal reabsorption of and secretion of . Study with Quizlet and memorize flashcards containing terms like Gluconeogenesis occurs in the liver due to the action of . 4 5 It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. renal pelvis. Glomerular filtration is the bulk flow of protein-free plasma from the glomerular capillaries into Bowman&39;s capsule. The classical understanding of RAAS is that it comprises three. What are the contraindications of ARBs Potassium sparing diuretics, salt substitutes, liver damage, and renal disorder. - Inner section of each adrenal gland; secretes epinephrine and norepinephrine. Antidiuretic hormone (ADH) stimulates water reabsorption in the collecting duct to form a small volume of concentrated urine. Study with Quizlet and memorize flashcards containing terms like Step 1, Step 2, Step 3 and more. Inactive prohormone converted in lung capillaries to Angiotensin II (active) by ACE (made in lungs and renal endothelium). is regulated by renin-angiotensin system. , Epinephrine and norepinephrine are hydrophilic hormones that. presence increases. B) increased blood glucose levels. androgens c. - Primary hyperaldosteronism (Conn&39;s syndrome) diagnosed in adults results from excessive secretion of aldosterone from one or both adrenal glands, usually caused by an adrenal adenoma. The hypersecretion of which hormone could lead to his condition, Harrie has recurring kidney stones. Aldosterone triggers sodium ion and so water reabsorption. Atrial natriuretic peptide (ANP) stimulates the. A) True B) False 46. It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. Step 2 Connect two terms to form a connection called a proposition. The adrenal medulla forms the outer portion of the adrenal glands, while the adrenal cortex forms the inner portion of the adrenal glands. Aldosterone triggers sodium ion and so water reabsorption. Where does obligatory water reabsorption occur 4. ) A. Na & H2O excretion increases. 42 terms. Prevent the digested material from becoming too acidic, Water occupies two main fluid compartments within the body,. Thyroxide and Triiodothyronine. 1. Study with Quizlet and memorize flashcards containing terms like The single most important factor influencing potassium ion secretion is . , Drag each label to the appropriate position to identify whether the label indicates a cause or effect of. Exchanges of hydrogen ions and potassium ions take place in alpha-intercalated cells, which are found at the end of the distal tubule and collecting duct. Blood plasma and lymph E. Access free multiple choice questions on this topic. Cortisol and aldosterone are hormones released by the adrenal glands, which are located at the top of each kidney. atrial natriuretic peptide. Aldosterone acts on the DCT of the kidney tubules to reabsorb greater amounts of sodium from the tubular fluid. It regulates both the reabsorption of sodium and the secretion of potassium. sex hormones, Cortisol, Aldosterone, progesterone - come from adrenal gland - Hydrophobic (bound to carrier proteins). Angiotensin II targets the adrenal cortex, telling it to secrete aldosterone. A) a person consumes excessive amounts of antacids B) a person's breathing is shallow due to. Aldosterone is a steroid hormone secreted by adrenal glands. Study with Quizlet and memorize flashcards containing terms like Aldosterone promotes the homeostasis of ions by causing the kidneys to. Study with Quizlet and memorize flashcards containing terms like Renin Angiotension Aldosterone Mechanism, When there is a drop in blood pressure, the juxtaglomerular cells respond by secreting which of the following, negatively charged proteoglycans found in the prevent most proteins in the blood from exiting the glomerular capillaries and more. Study with Quizlet and memorize flashcards containing terms like Aldosterone and renin each function to promote a. Aldosterone antagonists. Cells that secrete this hormone are found in the zona glomerulosa. Study with Quizlet and memorize flashcards containing terms like The definitive diagnosis of primary adrenal insufficiency requires. - by facilitated diffusion - through transmembrane proteins - by secondary active transport - into the peritubular capillaries - All of the above are correct. Study with Quizlet and memorize flashcards containing terms like Which statements about fluid in the human body are true (select all that apply) a. Hyperaldosteronism. Study with Quizlet and memorize flashcards containing terms like The definitive diagnosis of primary adrenal insufficiency requires. almost exclusively in the adrenal cortex. stimulates the conversion of noncarbohydrates (e. Testosterone is produced by the . Renin-angiotensin system "Renin-Angiotensin-Aldosterone System" Enzyme-hormone system that participates in. Study with Quizlet and memorize flashcards containing terms like Which of these hormones causes the kidney to increase the body's content of sodium antidiuretic hormone (ADH) parathyroid hormone (PTH) calcitonin aldosterone, Which of the following descriptions best fits the acid-base disorder respiratory acidosis 1. Study with Quizlet and memorize flashcards containing terms like Match each gland with its descriptionfunction. Study with Quizlet and memorize flashcards containing terms like Where is the greatest volume of water in the body found A. Prevent the digested material from becoming too acidic, Water occupies two main fluid compartments within the body,. It signals to your organs, like your colon and. Study sets, textbooks, questions. ) Aldosterone causes water loss that would contribute to the dehydration. Which teaching will the nurse include, The nurse is administering valsartan to a patient with hypertension at 0800. increases collecting duct's permeability to water --> to increase water reabsorption. The hormone is secreted by the pituitary gland and stimulates uterine contractions during childbirth. D) glucocorticoids. Bone serves as a mineral reserve for which two ions a. , The pancreas has pancreatic islets composed of primarily alpha and beta cells. The hormone stimulates the secretion of estrogen and the growth of eggs in the ovaries of the female. Functions of Aldosterone. Study with Quizlet and memorize flashcards containing terms like What is the function of. While it doesn&x27;t. Aldosterone is a steroid hormone (mineralocorticoid family) produced by the outer section (zona glomerulosa) of the adrenal. Step 2 Connect two terms to form a connection called a proposition. enhanced sodium ion loss in urine. hypocalcemia and. Study with Quizlet and memorize flashcards containing terms like Aldosterone gland, Aldosterone target cells,. Renin converts angiotensinogen to angiotensinI. The major function of Glucocorticoids on Carbs is -Increases glucose in the bloodstream. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. stimulates development of the follicle in the ovaries. Study with Quizlet and memorize flashcards containing terms like What is the function of. , Dilute urine is more likely to be produced when . Aldosterone is the primary of several endogenous members of the class of mineralocorticoids in humans. Decrease the production of aldosterone 3. , Epinephrine and norepinephrine are hydrophilic hormones that. As a consequence, blood. regulated by renin- angiotensin system. Which of the following statements is FALSE regarding water intake and output by the body An increase in the amount of beverages taken by mouth would increase the urine output. B) Aldosterone increases sodium reabsorption by. Study with Quizlet and memorize flashcards containing terms like What is the function of. put the elements of the renin-angiotensin-aldosterone cascade in order, from stimulus at the top to end product at the bottom. Produces diuresis, lowers BP. "Always Digging Holes" in collecting duct - to allow reabsorption of water. Study with Quizlet and memorize flashcards containing terms like What is the function of bile a. A) the feeling one might have after a long swim B) the unpleasant feeling people have after drinking too much. Denature proteins to assist in their absorption d. E) the proximal tubule. A (alpha cells) Insulin is produced by cells of the pancreatic islets called A) alpha cells. Where does most nutrient reabsorption occur. Study with Quizlet and memorize flashcards containing terms like Filtration is a process that depends on a gradient. Decrease in Na delivery to macula densa of the JG apparatus. One function of aldosterone is to indirectly stimulate the reabsorbtion of water from the kidney tubule cells into the systemic circulation. (RAAS) THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. Study with Quizlet and memorize flashcards containing terms like Match each gland with its descriptionfunction. Which gland produces both aldosterone and cortisol adrenal cortex. stimulates the conversion of noncarbohydrates (e. Aldosterone directly increases salt and water reabsorption into the bloodstream from the kidney. Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. Aug 22, 2023 Renin-Angiotensin-Aldosterone System. and more. A buffalo hump is a clinical manifestation of Cushing&39;s syndrome. Aldosterone is a mineralocorticoid hormone produced in the zona glomerulosa of the adrenal cortex that influences water and salt regulation in the body. Step 1 Drag a linking phrase into the workspace. Choose from 1,055 different sets of aldosterone flashcards on Quizlet. The effects of aldosterone on the regulation of body fluid ion concentration were first described in 1952 by James Tait, Sylvia Simpson, and Hilary Grundy. Interferes w sodium reabsorption by inhibiting aldosterone in distal tubule. Antidiuretic hormone (ADH) stimulates water reabsorption in the collecting duct to form a small volume of concentrated urine. (c) decreased plasma chloride. 5, pCO245mmHg, and HCO3-30mEqL. It is a part of a mineralcorticoid group,. Stimuli for its excretion are elevated serum potassium and angiotensin II. Which of the following is not a role of calcium in the body It is a significant component of nucleic acids. Study with Quizlet and memorize flashcards containing terms like Gluconeogenesis occurs in the liver due to the action of . All the following are features of potassium in nutrition except. Which gland secretes melatonin pineal. Study with Quizlet and memorize flashcards containing terms like Aldosterone release leads to, Renin is released when the, Blood osmolarity is sensed by the and more. 23) Growth hormone solely exerts its influence by targeting other endocrine glands to produce hormones. Aldosterone regulates epithelial sodium channel (ENaC) activity and degradation. Study with Quizlet and memorize flashcards containing terms like The single most important factor influencing potassium ion secretion is . Barton Top Questions What is aldosterone What is aldosterone's role in the body What. Study with Quizlet and memorize flashcards containing terms like Name the two types of cells in the cortical collecting ducts and describe their function. the specific gravity of the urine decreases more urine is produced less water is reabsorbed. , In a typical. ADH release is stimulated. do not change. The adrenal medulla forms the outer portion of the adrenal glands, while the adrenal cortex forms the inner portion of the adrenal glands. Increased aldosterone, as in the case of hyperaldosteronism, results in A) decreased serum osmolarity. In hyperaldosteronism, overproduction of the hormone aldosterone leads to fluid retention and increased blood pressure, weakness, and, rarely, periods of paralysis. The outer layer secretes what hormone. it compensates for a decline in blood pressure or blood volume by prompting the distal convoluted tubules and collecting ducts of the kidneys to resorb more sodium into the blood. Hyperkalemia D. Study with Quizlet and memorize flashcards containing terms like Select all that apply. Graves' disease. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. Angiotensin I. B) respiratory rate increases. 3) stimulates hepatic gluconeogenesis. stimulates glycogenesis b. The nurse reviewing this patient's chart before administering the medication will be most concerned about which other disease process a. Helps regulate BP, blood volume, and fluid & electrolyte balance. , In response to respiratory alkalosis, the A) kidneys retain more hydrogen ions. An aldosterone test measures the levels of a hormone that is important in keeping your blood pressure in check. Match the correct outcome with its causative glomerular regulation factor Afferent arterioles constrict in response to a rise in blood pressure, thus restricting the flow of blood into the glomerulus. the proximal convoluted tubule. Aldosterone antagonists. Aldosterone is a hormone excreted by the adrenal cortex and it is involved in regulating the balance of water and electrolytes in the body, more accurately sodium and potassium in the blood. Break down fats to assist their chemical digestion b. Click the card to flip . RAAS stands for Renin-Angiotensin-Aldosterone System. B) the loop of Henle. ) Aldosterone causes water loss that would contribute to the dehydration. Click the card to flip . Assist in the digestion of starches c. The distal convoluted tubule is affected by aldosterone. Cortisol and aldosterone are produced. The mass of each object is 30 &92;mathrm kg 30 kg. Aldosterone is a mineralocorticoid hormone. Glomerular filtration is the bulk flow of protein-free plasma from the glomerular capillaries into Bowman's capsule. and more. The pituitary gland is connected ot the hypothalamus. regulated by renin- angiotensin system. demosaichentai, kalispell mt jobs
, Which of the following glomerular regulators responds to filtrate NaCl concentrations, Which of the following substances is typically used to measure the GFR and more. . Aldosterone quizlet
Its main role is to regulate salt and water in the body, thus having an effect on blood pressure. enhanced sodium ion loss in urine. steroid hormones See all media Category Science & Tech Sir Derek H. and more. Study with Quizlet and memorize flashcards containing terms like Gluconeogenesis, the formation of glucose from fats and proteins, is due to the action of . Study with Quizlet and memorize flashcards containing terms like Aldosterone stimulates reabsorption of sodium ions in the late distal convoluted tubule and collecting duct. Study with Quizlet and memorize flashcards containing terms like Place the steps of the renin-angiotensin-aldosterone system (RAAS) in order. , Virtually all amino acid-based hormones. , Aldosterone is stimulated by an increase or decrease in what ions, What does aldosterone increase in the basolateral membrane and more. Hypotension, Which of the following occurs when blood volume and pressure become too high A. juxtaglomerular cells stimulated. cortisol (hydrocortisone) a corticosteroid that has an antiinflammatory action, regulates the metabolism of carbohydrates, fats, and proteins in the body. Scheduled maintenance Thursday, January 26 from 6PM to 7PM PST. The renin-angiotensin-aldosterone system (RAAS) is a critical regulator of blood volume, electrolyte balance, and systemic vascular resistance. Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in the adrenal cortex. HTN with hypokalemia. It is part of the renin angiotensin aldosterone system or RAAS and is an integral part of the complex mechanisms that control water and electrolyte balance within the body. Study with Quizlet and memorize flashcards containing terms like hormone, endocrine hormone, exocrine hormone and more. Levine, Kenneth R. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. A) decreased blood pressure. hormone produced by the adrenal gland. Angiotensin II Aldosterone ADH ANP, label the structures of a capillary bed, Drag each label into the appropriate position to identify whether the characteristic is indicative of arteries or veins. Study with Quizlet and memorize flashcards containing terms like Filtration is a process that depends on a gradient. Step 3 Connect all the propositions to. Might any of these drugs cause adverse effects If so, what are the potential adverse effects of each drug. Click the card to. Diagram the control of thyroid hormone secretion. alcohol contains caffeine. Study with Quizlet and memorize flashcards containing terms like An increase in fluid taken by mouth would reduce the amount produced by metabolism. increases collecting duct&39;s permeability to water --> to increase water reabsorption. Aldosterone is a steroid hormone, "the main mineralocorticoid hormone", produced by the. Too much aldosterone secretion Hypertension, hypernatremia, hypokalemia, alkalosis; Study with Quizlet and memorize flashcards containing terms like What is the major osmotically active solute in the extracellular fluid, What is aldosterone, Zone of adrenal cortex. Interferes w sodium reabsorption by inhibiting aldosterone in distal tubule. Secondary hyperaldosteronism is usually due to high blood pressure. ) Blood pressure increases as salt intake rises b. Study with Quizlet and memorize flashcards containing terms like stimulates Na reabsorption and k secretion, increasing. a disorder of the adrenal glands that is caused by the excessive production of aldosterone. Study with Quizlet and memorize flashcards containing terms like Total body water volume is divided into, What two things does our body modify to regulate our volume status, Renin-Angiotensin-Aldosterone System and more. B) increased blood glucose levels. For aldosterone, both and kidney and concentrations are used as signals to. The nurse reviewing this patient's chart before administering the medication will be most concerned about which other disease process a. - Outer section of each adrenal gland; secretes cortisol, aldosterone and sex hormones. A) aldosterone B) insulin C) secretin D) cortisol, Normal development of the immune response is due in part to hormones produced by the . Hypertension is often treated with drugs called ACE inhibitors which block the action. angiotensin II targets blood vessels in adrenal cortex. Thiazide diuretics treat hypertension because they 1. The symptoms of adrenal crisis include hyperkalemia, a drop in extracellular fluid volume, and hyponatremia. , Aldosterone promotes renal reabsorption of and secretion of . Study with Quizlet and memorize flashcards containing terms like where is aldosterone secreted, what stimulates the release of aldosterone, what does ANP promote and more. What leads to an increase in hormone levels when hormone levels rise above normal Find step-by-step Anatomy and physiology solutions and your answer to the following textbook question Which of these is not a hormone secreted by the adrenal cortex a. As a result . Excessive levels of cortisol or aldosterone. Which hormone should be checked for normal levels and more. Antidiuretic Hormone. CHD4537 Lecture 6. , Identify the most accurate cause or outcome of the situation described on each label. Study with Quizlet and memorize flashcards containing terms like Aldosterone is released from the in response to . ) retention of sodium c. The distal convoluted tubule is affected by aldosterone. < if have any hepatic disease >> buildup of aldosterone. Positive feedback c. Deficiency in these steroid hormones can cause serious health problems and even death. The the outer layer secretes what hormone. ) Aldosterone would cause sodium secretion, causing osmosis and further water loss. , Aldosterone is stimulated by an increase or decrease in what ions, What does aldosterone increase in the basolateral membrane and more. Deoxycorticosterone is another important member of. Choose from 1,055 different sets of aldosterone flashcards on Quizlet. Promote sodium & H2O excretion, K retention. Releasing and inhibiting hormones. a congenital form of hypothyroidism. Transcellular fluid, Most body water intake is from , whereas most body water lost is via . Study with Quizlet and memorize flashcards containing terms like Adrenal Medulla, Adrenal Cortex, steroid, intracellular and more. aldosterone, Aldosterone A. High blood sodium concentration E. plasma glucose levels D. C) increased sodium excretion coupled with retention of potassium. is linked to blood pressure. Positive feedback c. Design a concept map based on the topic using all terms and linking phrases at least once. Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. All the following are features of potassium in nutrition except. Study with Quizlet and memorize flashcards containing terms like What is the goal of the renin-angiotensin-aldosterone system (RAAS), When the RAAS is activated due to a change in body hemodynamics, the stimulates the cells in the kidneys to release . -Component of all body cells, giving structure and form to the body. Study with Quizlet and memorize flashcards containing terms like Identify a difference between the adrenal medulla and the adrenal cortex. The hormone aldosterone affects kidney tubule function. C) increased sodium excretion coupled with retention of potassium. Bone serves as a mineral reserve for which two ions a. B) increased blood glucose levels. Where does counter current multiplication occur 4. sex hormones, Cortisol, Aldosterone, progesterone - come from adrenal gland - Hydrophobic (bound to carrier proteins). Vasopressin is produced by the hypothalamus and released by the pituitary gland in response to high blood osmolality or low blood volume. Intracellular fluids have high concentrations of. Aldosterone (ALD) is a hormone your adrenal glands release that helps regulate blood pressure by managing the levels of sodium and potassium in your blood. Answer TRUE. Diabetes mellitus d. Endo Lecture 1 824. 0 (1 review) List the roles of water in the body. For aldosterone, both and kidney and concentrations are used as signals to. What leads to an increase in hormone levels when hormone levels rise above normal Find step-by-step Anatomy and physiology solutions and your answer to the following textbook question Which of these is not a hormone secreted by the adrenal cortex a. This amount is not dependent on the amount of water taken by mouth, antidiuretic hormone (ADH), hypotonic hydration and more. -Conn&39;s syndrome. 23) Growth hormone solely exerts its influence by targeting other endocrine glands to produce hormones. Hypotension, Which of the following occurs when blood volume and pressure become too high A. Addison's disease is a condition that occurs when the adrenal glands do not produce enough of the hormones cortisol or aldosterone. The primary target organ of aldosterone is . Match the following five hormones with their functions. Go to Introduction Aldosterone is a mineralocorticoid hormone. Study with Quizlet and memorize flashcards containing terms like Aldosterone stimulates reabsorption of sodium ions in the late distal convoluted tubule and collecting duct. ANH is released. Renin is an enzyme that leads to a series of. Might any of these drugs cause adverse effects If so, what are the potential adverse effects of each drug type a. and more. B) respiratory rate increases. high blood pressure with hypokalemia alkalosis. B) parathyroid glands. Helps regulate BP, blood volume, and fluid & electrolyte balance. E) gallbladder. . bathroom sink faucets lowes