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The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted central side effects of both agonists (in wasting disorders) or antagonists (in obesity and diabetes) have limited their therapeutic utility. rimonabant, taranabant) of the cannabinoid type-1 (CB (1)) receptor have been explored as therapeutic agents in diverse fields of medicine such as pain management and obesity with associated metabolic dysregulation, re. Cb 1 weight gainer side effects. The effects of peripheral CB1 activation in promoting appetite, food storage, and weight gain. How to Effectively Lose Weight. You have nothing to lose, only weight to gain. CB1 weight gainer is a weight gain pill that is marketed to help the user gain weight. Ask Your Question Fast. CB-1 says that all of its components are. For example, some users have reported experiencing side effects like bloating, stomach discomfort, and diarrhea. Read more about safety and side-effects. support supragenix. 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