Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. Research Article Metabolism Muscle biology Free access 10. Previous Issue Next Issue. PD-1 CXCR5 - CD4 Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma. Used without definition; All others are defined at first mention, with the abbreviated form appearing in parentheses e. Research Article Dermatology Inflammation Open Access 10. Limiting this effect, or increasing BAMBI, improved RT-induced tumor cell killing, tumor response, and antitumor immune effects. Cyclooxygenase-dependent tumor growth through evasion of immunity. Associate Editors. Am J Med Sci. BM neutrophils were treated with IL-12 (40 ngmL) for indicated time points. Dubner, , Mark W. Ajay, 1 Ashwin Iyer, 1 Sarah Boswell, 2 John N. Protein kinase C and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities. Togashi Y, et al. View this article via JCI Insight PubMed Google Scholar Southwell AL, et al. Brown, 1 Xiuyin Liang, 1 Silvia Medrano, 1 Shin Goto, 2 Ichiei Narita, 2. On the cover Pathological activation of MAPK causes lymphangiectasia treatable with ravoxertinib. 148960 Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment. It was established in 1924 and is published by the American Society for Clinical Investigation, one of the oldest and most respected medical honor societies in the United States. Geometric distribution of retinal A deposits in AD patients. JCI Insight. Gentles AJ, et al. How to prepare your revised manuscript for submission. Previous Issue Next Issue. 165566 EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids. Its formation is orchestrated by complex interactions among tumor cells, inflammatory cells, and the vasculature. Hereditary hypophosphatemic disorders are associated with FGF23 excess, impaired skeletal growth, and osteomalacia. Meanwhile, TGFBR2-edited CAR T cells had better in vivo tumor elimination efficacy, both in cell line-derived xenograft and patient. Our in vitro data indicate that this glucagon activity is primarily due to glucagon-dependent stimulation of cell GLP-1 receptors, both in mouse and human islets. Liu 1,2. 137799 The laboratory tests and host immunity of COVID-19 patients with different severity of illness Feng Wang, 1 Hongyan Hou, 1 Ying Luo, 1 Guoxing Tang, 1 Shiji Wu, 1 Min Huang, 1 Weiyong Liu, 1 Yaowu Zhu, 1 Qun Lin, 1 Liyan Mao, 1 Minghao Fang, 2 Huilan Zhang. Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. Research In-Press Preview Cell biology Vascular biology Open Access 10. View this article via JCI Insight PubMed Google Scholar. JCI Insight. Jan 26, 2021 Abstract. PD-1PD-L1 checkpoint therapy for cancer is commonly considered to act by reactivating T cells in the tumor microenvironment. 157963 Binding and neutralizing antibody responses to SARS-CoV-2 in very young children exceed those in adults Ruth A. Alveolar Macrophage Transcriptional Programs Are Associated with Outcomes in Acute Respiratory Distress Syndrome. Physical activity and muscle-brain crosstalk. 124952 Hyperglycemia induces skeletal muscle atrophy via a WWP1KLF15 axis Yu Hirata, 1 Kazuhiro Nomura, 1 Yoko Senga, 1 Yuko Okada, 1 Kenta Kobayashi, 2,3 Shiki Okamoto, 3,4,5 Yasuhiko Minokoshi, 3,4 Michihiro Imamura, 6. Research In-Press Preview Immunology Nephrology Open Access 10. In line with previous findings (25, 26), we detected higher luciferase signal in 12- compared with 3-month-old p16-Luc mice and an induction of other classic senescence biomarkers (by transcriptomic analysis Cdkna2 and Cdkna1; by staining p16, p21, and p53; Figure 1, B and C, and Supplemental Figure 1, A and B; supplemental material. View this article via JCI Insight CrossRef PubMed Google Scholar Li JP, et al. Acute kidney injury developed in 41 patients (23. Research In-Press Preview Cardiology Open Access 10. Research Article Cell biology Nephrology Open Access 10. Identification of NK cells and ILC3-like cells in melanoma metastases. 3 Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. View this article via JCI Insight PubMed Google Scholar Rowan CM, et al. J Immunol. An equal number (4736 cells). Arend, 3. Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations. 7 of cells) were identified in human melanoma metastases. Tmtc4 -KO mice have rapidly progressive postnatal hearing loss due to overactivation of the unfolded protein response (UPR); however, the cellular basis and human relevance of Tmtc4 -associated hearing loss in the cochlea was not heretofore. 157421 Low c-Kit expression identifies primitive, therapy-resistant CML stem cells Mansi Shah, 1 Harish Kumar, 1 Shaowei Qiu, 1,2 Hui Li, 1 Mason Harris, 1 Jianbo He, 1 Ajay Abraham, 1 David K. 6 Welbio and Institute for Medical Immunology, Universit&233; Libre de Bruxelles, Brussels, Belgium. Research Article Neuroscience Open Access 10. Ajay, 1 Ashwin Iyer, 1 Sarah Boswell, 2 John N. The objective of this study is to evaluate the effect of repetitive IL-15 exposure on NK cells. 99488 Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model Benjamin Y. Morrell ED, et al. Physical activity and muscle-brain crosstalk. JCI Insight is a monthly online journal that publishes original research articles from the fields of clinical investigation, translational medicine, and biomedical research. JCI Insight. A role of CD4 T cells during the progression from nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) has been suggested, but which polarization state of these cells characterizes this progression and the development of fibrosis remain unclear. Clinical diagnosis of acute interstitial nephritis (AIN) is challenging because of lack of a diagnostic biomarker and requires a kidney biopsy. Long, 2 Amanda Tchakarov, 3 Yanlan Dong, 4 Cassian Yee, 1 and Jamie S. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. Research Article Endocrinology Metabolism Free access 10. 167440 LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function. Livingston, 2 Zhengwei Ma, 2 Xiaoru Hu, 1,2 Lu Wen, 1,2 Han-Fei Ding, 3 Daohong Zhou, 4 and Zheng Dong 1,2,5. PD-1 CXCR5-CD4 Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma. Published August. Martini, 1 Evan A. describe the immune landscape of primary Sjogrens syndrome and characterize the differentiation trajectory of CD8 tissue-resident. Research Article Metabolism Muscle biology Free access 10. Figure 6. J Cereb Blood Flow Metab. Sep 5, 2023 JCI Insight. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy a randomised, controlled, open-label, phase 3 trial. We hypothesize that sterol regulatory element-binding protein 2 (SREBP2) plays a critical role. TTS confers an in-hospital mortality rate similar to that of acute coronary syndromes (. The Journal takes all publishing behavior violations seriously, and suspected cases will be fully reviewed. PMID 30674722. Xie et al. 161229 Targeting activin receptorlike kinase 7 ameliorates adiposity and associated metabolic disorders Min Zhao, 1 Katsuhide Okunishi, 1 Yun Bu, 1 Osamu Kikuchi, 2 Hao Wang, 1 Tadahiro Kitamura, 2 and Tetsuro Izumi 1. Research Article Endocrinology Nephrology Open Access 10. JCI Insight. Research Article Nephrology Vascular biology Open Access 10. , "sensory long-term facilitation (sLTF)" and used without definition thereafter; Gene and protein names and symbols Conform to official NCBI Gene Nomenclature. We used high-throughput transcriptomic profiling to perform a comparative analysis of lncRNAs in neuroblastoma (high-risk and undifferentiated, n 5), intermixed ganglioneuroblastoma (low-risk and differentiating, n 4), and ganglioneuroma maturing subtype (n 4) samples (Supplemental Table 1; supplemental material available online with this. May 4, 2017 Introduction. JCI Insight. 93397 Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. Research Article COVID-19 Immunology Open Access 10. Clinical Medicine COVID-19 Infectious disease Open Access 10. Rayes, 1 Jack G. 09 mmy 0. Therefore, BACE2 contributes to AD pathogenesis as a conditional -secretase and could be a preventive and therapeutic target for AD without the side effects of BACE1 inhibition. View this article via JCI Insight PubMed Google Scholar. Volume 7, Issue 17. 126453 Single-cell transcriptomicsbased MacSpectrum reveals macrophage activation signatures in diseases Chuan Li, 1 Antoine Menoret, 1,2 Cullen Farragher, 3 Zhengqing Ouyang, 2,4,5,6 Christopher Bonin, 7 Paul Holvoet, 8 Anthony T. 3 Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Inhibition of murine neutrophil recruitment in vivo by CXC chemokine receptor antagonists. 5 Department of Biomedical Data. Here, we present data from 2 mouse tumor models demonstrating an essential involvement of tumor-draining lymph nodes in PD-1 and PD-L1 therapeutic efficacy. JCI Insight. JCI Insight is an open access journal that has a 2019 Impact Factor of 6. This fee supports the following expenses Editorial Board and staff. View this article via JCI Insight CrossRef PubMed Google Scholar. Nat Med. Research Article Gastroenterology Open Access 10. describe the immune landscape of primary Sjogrens syndrome and characterize the differentiation trajectory of CD8 tissue-resident. View this article via JCI Insight PubMed Google Scholar Wu H, Uchimura K, Donnelly EL, Kirita Y, Morris SA, Humphreys BD. doi 10. Figure preparation. Tmtc4 -KO mice have rapidly progressive postnatal hearing loss due to overactivation of the unfolded protein response (UPR); however, the cellular basis and human relevance of Tmtc4 -associated hearing loss in the cochlea was not heretofore appreciated. Resource and Technical Advance Oncology Open Access 10. 1 Department of Immunology and Genomic Medicine,. Pedersen BK. Volume 8, Issue 8. McColl SR, Clark-Lewis I. Allegakoen, 1 Jos A. 3 Inserm UMR-1092, University of Limoges, Limoges, France. Hutchinson, 3 Sushrut S. 170739 Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease Shivam A. 2019 Mar 7;4(5)e124865. Standard JCI Insight abbreviations and acronyms may be used without definition; all others are defined at first mention (with the abbreviated form appearing in parentheses) and used without definition thereafter. Top read articles in the last 30 days. Brown, 1 Xiuyin Liang, 1 Silvia Medrano, 1 Shin Goto, 2 Ichiei Narita, 2 Lois J. Resource and Technical Advance Development Stem cells Open Access 10. (A and B) Identification of NK cell and ILC3 cell populations. In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to respiratory failure. To determine if the predicted differentiation trajectories are biologically meaningful, we compared the retinal microglia data from our study with a scRNA-Seq data set of more than 76,000 microglia throughout a. Delay in onset by CD19IgM cotransfers is independent of Tregs. IL-33 stimulates the secretion of IL-13 by murine ST2 Tregs. Research Article Pulmonology Stem cells Open Access 10. JCI Insight is a journal of the Journal of Comparative and International Health that publishes original research articles on health systems and health care. 2 Inserm CIC-1435, Dupuytren University Hospital, Limoges, France. Graphical Abstract. 2 Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA. Top read articles in the last 30 days. Lin 4. 039 and Z 2. The human brain produces fructose from glucose Janice J. 2 Inserm CIC-1435, Dupuytren University Hospital, Limoges, France. View this article via JCI Insight CrossRef PubMed Google Scholar Russell S, et al. Sherwin 1. JCI Insight. 154337 Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans Hirofumi Watanabe, 1,2 Alexandre G. Gudjonsson Nobuhiko Kamada Nicholas W. The JCI Insight Editorial Board Editor. 2019 Mar 7;4(5)e124865. Wu H, Uchimura K, Donnelly EL, Kirita Y, Morris SA, Humphreys BD. View this article via JCI Insight PubMed Google Scholar Stortz JA, et al. N Engl J Med. JCI Insight. 154142 Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy Suzan M. Resource and Technical Advance Immunology Free access 10. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. 2 Department of Bioregulation, Institute for Advanced Medical Sciences, Nippon Medical School, Kawasaki, Kanagawa, Japan. 2 Breast Cancer Translational Research Laboratory,. Research Article Metabolism Neuroscience Open Access 10. 154337 Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans Hirofumi Watanabe, 1,2 Alexandre G. JCI Insight is owned and self-published by the American Society for Clinical Investigation, based in Ann Arbor, Michigan. However, there is little evidence regarding. Physical activity and muscle-brain crosstalk. Schappell, 1 Stephen D. Gao, 1 Nathan Salomonis, 2,3 Maggie Henderlight, 1 Christopher Woods, 4 Kairavee Thakkar, 3 Alexei A. 18 Citations 22,234 Open Access Support. 2019 Jun 20;4(12)e128308. Usage information is collected from two different sources this site (JCI) and Pubmed Central (PMC). The latest issue features articles on topics such as brain-penetrant radiosensitizer, heterogeneous cardiac innervation, prenatal effector cells, and more. Sarkar, 3 Shaun Egolf, 4 Jonathan Zou, 4 Afua Tiwaa, 1 Brian C. 2019 Mar 7;4(5)e124865. Am J Med Sci. Physical activity and muscle-brain crosstalk. 2 Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy. To this end, we performed Western blot analysis on human retina cadaver tissue lysates from patients with DR and observed increased expression of STING and cGAS in the retina of donors with DR compared with nondiabetic control donors (Figure 1, AC, and Supplemental Table 1; supplemental material available online with this article;. Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. On the cover Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies. Maximum width, entire figure 918 cm (3. View this article via JCI Insight PubMed Google Scholar Subramanian A, et al. Research Article Immunology Inflammation Open Access 10. The Journal of Clinical Investigation (JCI) is a twice-monthly peer-reviewed medical journal covering biomedical research. View this article via JCI Insight CrossRef PubMed Google Scholar Contreras-Ruiz L, Masli S. craigslist saint louis mo, live tiktok nudes
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Participants received either etokimab (n 15) or blinded placebo (n 5). Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. Clinical tests included oral food challenges and skin prick tests at days 15 and 45. demonstrate that progerin causes nuclear membrane ruptures in aortic smooth muscle cells in a mouse model of Hutchinson-Gilford progeria syndrome (HGPS). Jin, 1 Tracy E. Togashi Y, et al. Annu Rev Immunol. Research Article Gastroenterology Open Access 10. View this article via JCI Insight PubMed Google Scholar. 1 Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Acute kidney injury developed in 41 patients (23. Crompton et al. 156529 Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment. 074, respectively) (Figure 4, blue genes. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, microbicidal proteins, and oxidant enzymes that are released by neutrophils to contain infections. Research Article Cell biology Oncology Open Access 10. submissions are available here. J Immunother Cancer. 7 of cells) were identified in human melanoma metastases. Martini, 1 Evan A. JCI Insight is an open access journal that has a 2019 Impact Factor of 6. Weirather, 1 Caron Jacobson, 2 Philippe Armand, 2 Kyle Wright, 3 F. Research Article Oncology Free access 10. 157421 Low c-Kit expression identifies primitive, therapy-resistant CML stem cells Mansi Shah, 1 Harish Kumar, 1 Shaowei Qiu, 1,2 Hui Li, 1 Mason Harris, 1 Jianbo He, 1 Ajay Abraham, 1 David K. For inquiries regarding a specific manuscript, use the email address shown above, and reference the manuscript number assigned by the Journal (for example, 154280-INS-RG-1). Am J Respir Crit Care Med. Taylor, 3 Michelle van der Vlugt-Daane, 2 Paul Hamberg, 4 Ronald. JCI Insight. Inositol 1, 4, 5-trisphosphate receptormediated (IP 3 R-mediated) calcium (Ca 2) release has been proposed to play an important role in regulating vascular smooth muscle cell (VSMC) contraction for decades. Since CD318, a novel CD6 ligand, is associated with the aggressiveness and metastatic potential of human cancers, we tested the effect of an anti-CD6 monoclonal antibody, UMCD6, on killing of cancer cells. (A) PBT030-2 GBM cells were cocultured with CD4 or CD8 CAR T cells at ET ratios of 14, 16, 110, and 120, and the numbers of viable tumor cells were enumerated at the denoted time points. Fajardo, 2,4 Yue Pan, 1 Max A. Brown, 1 Xiuyin Liang, 1 Silvia Medrano, 1 Shin Goto, 2 Ichiei Narita, 2 Lois J. Maria Castro is Professor of Neurosurgery and of Cell and Developmental Biology at the University of Michigan Medical School. 157421 Low c-Kit expression identifies primitive, therapy-resistant CML stem cells Mansi Shah, 1 Harish Kumar, 1 Shaowei Qiu, 1,2 Hui Li, 1 Mason Harris, 1 Jianbo He, 1 Ajay Abraham, 1 David K. (A) Tregs were analyzed from splenocytes of NOD. 2019 Mar 7;4(5)e124865. Clark, 1 Qinkun Zhang, 2 Lehanna H. (A and B) Identification of NK cell and ILC3 cell populations. Campbell, 1 Lindsey M. 124952 Hyperglycemia induces skeletal muscle atrophy via a WWP1KLF15 axis Yu Hirata, 1 Kazuhiro Nomura, 1 Yoko Senga, 1 Yuko Okada, 1 Kenta Kobayashi, 2,3 Shiki Okamoto, 3,4,5 Yasuhiko Minokoshi, 3,4 Michihiro Imamura, 6 Shinichi Takeda, 6 Tetsuya Hosooka, 1 and. 170739 Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease Shivam A. The Journal of Clinical Investigation (JCI) is a twice-monthly peer-reviewed medical journal covering biomedical research. Research Article Nephrology Open Access 10. CART therapy can result in severe adverse effects due to on-target, off-tumor toxicity, which arises in patients who have target antigen expressed on both tumor and healthy tissue. Colorectal cancer (CRC) ranks third among the most common cancers, affecting both men and women worldwide. Crit Care Med. Vella, 1 and Beiyan Zhou 1,2. 0027) (Figure 5B). JCI Insight. Transmembrane and tetratricopeptide repeat 4 (Tmtc4) is a deafness gene in mice. Research Article Gastroenterology Open Access 10. JCI Insight is owned and self-published by the American Society for Clinical Investigation, based in Ann Arbor, Michigan. The Journal publishes well-executed, high-quality studies that provide meaningful contributions to the understanding of the biology andor treatment of disease, with an emphasis on clinically relevant basic and translational research. The latest issue features articles on topics such as brain-penetrant radiosensitizer, heterogeneous cardiac innervation, prenatal effector cells, and more. 4 CAS Key Laboratory of Molecular Virology &. Stephen Hodi, 1,2 Zachary J. 159093 Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation Mark Rochman, 1 Ting Wen, 1,2 Michael Kotliar, 1 Phillip J. Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. Articles from JCI Insight are provided here courtesy of American Society for Clinical Investigation. 170739 Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease Shivam A. RSV infection was also significantly lower in CD8 T celltransplanted LoM at 2 weeks after T cell transfer compared with nontransplanted controls (P 0. Simon, 1 Marco M. Research Article Nephrology Open Access 10. JCI Insight. Figure 2. 173095 Preliminary results of the European multicentric phase III trial regarding sirolimus in slow-flow vascular malformations. 8 in. View this article via JCI Insight CrossRef PubMed Google Scholar. Research Article Nephrology Open Access 10. 148960 Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment. The morphology of spermatozoa from P2 and P7 was analyzed using H&E staining of semen smears, and the results revealed that most spermatozoa from the 2 individuals had malformed flagella, including absent, short, coiled, bent, and irregular caliber, which are typical characteristics of MMAF (Table 1 and Supplemental Figure 1; supplemental. Arend, 3. 1 State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. Horlbeck, 5,6,7. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs). Research Article Nephrology Free access 10. Garcia, 2,3 Kristen Kwong, 1 Pushpendra K. Clinical information from the 8 iMCD-TAFRO patients who received IL-6 blockade with or without corticosteroids also revealed an important insight into treatment. 5 Flow Cytometry Core Facility, Institut Jules Bordet, Universit&233; Libre de Bruxelles, Brussels, Belgium. Taylor, 1 Darryl A. (A) Volcano plot depicting RNA-Seq analysis comparing ST2 Tregs stimulated for 6 hours in the presence (condition B) or absence of IL-33 (20 ngml) (condition A) revealed increased transcripts for Il10 and Il13 after IL-33 stimulation. (A) PBT030-2 GBM cells were cocultured with CD4 or CD8 CAR T cells at ET ratios of 14, 16, 110, and 120, and the numbers of viable tumor cells were enumerated at the denoted time points. 25 cm (6. JCI Insight. Figure 4. 6 Department of Pathology and. Andrew Lieberman is the Gerald D. . atx auctions utah